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Medication Nebulizers also referred to as small volume or jet nebulizers (SVN) are devices used to turn medication into an aerosolized mist to deliver directly into the patient's lungs. Inhaled aerosols have considerable advantages in the treatment of many lung diseases including bronchitis and cystic fibrosis. The required dose is much smaller compared to that taken systemically and the side effects are therefore negligible. The onset of the action is quicker, and the drug itself is more selective.
Nebulizer Performance. Important characteristics of nebulizer performance include the aerosol particle size generated, drug output, nebulizing time and the amount of drug delivered to the patient. device construction, fill volume, flow temperature, humidity of the driving gas are factors affecting the performance of a nebulizer.
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Aerosol Therapy Explained

Particle Size is an important characteristic of nebulizer performance. Large particles do not reach the lower respiratory tract depositing themselves in the mouth, upper airways and gastrict tract. Particles too small will not be taken up by the alveoli and are exhaled. Respirable particles taking part in lung deposition has been accepted to range from 0.5 microns to 5.0 microns in diameter size.
Nebulizing Time is the time from starting nebulization until continuous nebulization has ceased and depends on the flow rate, compressed air and the construction of the nebulizer. These are a major influence on aerosol size distribution. Optimal flow rates recommended are between 6-8 liters per minute, with 8l/min providing a smaller particle size and shorter nebulizer time, the time it takes for the volume to completely nebulize. A SVN should deliver at least 80% of the solution within 15 minutes.
Reconcentration is a SVN is greater at a diluent volume of 2ml than one of 4 ml and for that reason it is suggested 4ml maybe superior than 2ml as a diluent formula.
Dead Volume is the volume of medication not delivered to the patent during nebulization and exists as the volume left in the nebulizer at the end of nebulization.
Respirable Mass is the combination of aerosolized drug output and the percentage of particles in the respirable range. This is the amount of aerosolized drug available to the patient on inspiration.